Cyclodextrin-based host-guest complexes loaded with regorafenib for colorectal cancer treatment
oleh: Hongzhen Bai, Jianwei Wang, Chi Uyen Phan, Qi Chen, Xiurong Hu, Guoqiang Shao, Jun Zhou, Lihua Lai, Guping Tang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-02-01 |
Deskripsi
Regorafenib is a multi-kinase inhibitor in use for the treatment of colorectal cancer (CRC). To improve drug pharmacokinetics and bioavailability, here the authors design mannose-modified cyclodextrin-based host-guest complexes loaded with Regorafenib, showing anti-tumor responses in preclinical models of CRC.