TMSBr-mediated solvent- and work-up-free synthesis of α-2-deoxyglycosides from glycals
oleh: Mei-Yuan Hsu, Yi-Pei Liu, Sarah Lam, Su-Ching Lin, Cheng-Chung Wang
| Format: | Article |
|---|---|
| Diterbitkan: | Beilstein-Institut 2016-08-01 |
Deskripsi
The thio-additions of glycals were efficiently promoted by a stoichiometric amount of trimethylsilyl bromide (TMSBr) to produce S-2-deoxyglycosides under solvent-free conditions in good to excellent yields. In addition, with triphenylphosphine oxide as an additive, the TMSBr-mediated direct glycosylations of glycals with a large range of alcohols were highly α-selective.