Flow Cytometry and T-Cell Response Monitoring after Smallpox Vaccination

oleh: Fabrizio Poccia, Cristiana Gioia, Carla Montesano, Federico Martini, Douglas Horejsh, Concetta Castilletti, Leopoldo Paolo Pucillo, Maria Rosaria Capobianchi, Giuseppe Ippolito

Format: Article
Diterbitkan: Centers for Disease Control and Prevention 2003-11-01

Deskripsi

Orthopoxvirus zoonosis or smallpox as result of bioterrorism or biological warfare represents a risk for epidemic spread. By monitoring T-cell responses by flow cytometry, we observed a recall response after recent vaccination against smallpox. When the high similarity between the orthopoxviruses is considered, this rapid assay that uses vaccinia antigens could identify recently exposures.