Mobilization of peripheral blood stem cells in myeloma with either pegfilgrastim or filgrastim following chemotherapy

oleh: Guido Tricot, Bart Barlogie, Maurizio Zangari, Frits van Rhee, Antje Hoering, Jackie Szymonifka, Michele Cottler-Fox

Format: Article
Diterbitkan: Ferrata Storti Foundation 2008-11-01

Deskripsi

Quality and quantity of mobilized peripheral blood stem cells determine the safety of tandem autologous transplants in myeloma. Using the same mobilization chemotherapy with DT-PACE in two consecutive protocols, robustness of stem cell collection and rapidity of engraftment after transplantation were assessed. We employed either twice a day filgrastim versus two doses of pegfilgrastim. Advantages of pegfilgrastim were: (i) a higher percentage of patients collected 15×106/kg in the first three days (p