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Xiaohui Luo, Yan Zhao Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of ChinaCorrespondence: Yan Zhao, Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310000, People’s Republic of China, Tel +86 18346350883, Email 1152637095@qq.comAbstract: Low back pain (LBP) is common and has a complex etiology. Superior cluneal nerve (SCN) entrapment has come to the attention of pain physicians as a cause of LBP. SCN block is the mainstay of treatment for LBP due to SCN entrapment. The aim of this narrative review is to summarize the approaches and techniques for ultrasound-guided SCN block. Meanwhile, the evidence for the clinical use of SCN block is reviewed, based on relevant and recent literature. The authors expect this article to provide a reference point for the diagnosis and treatment of LBP.Keywords: superior cluneal nerve, ultrasound, low back pain