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Cell death is an important physiological phenomenon in life. It can be programmed or unprogrammed. Unprogrammed cell death is usually induced by abiotic or biotic stress. Recent studies have shown that many proteins regulate both cell death and immunity in plants. Here, we provide a review on the advances in plant immunity with cell death, especially the molecular regulation and underlying mechanisms of those proteins involved in both cell death and plant immunity. In addition, we discuss potential approaches toward improving plant immunity without compromising plant growth.