Limited clonal relatedness between gut IgA plasma cells and memory B cells after oral immunization
oleh: Mats Bemark, Helena Hazanov, Anneli Strömberg, Rathan Komban, Joel Holmqvist, Sofia Köster, Johan Mattsson, Per Sikora, Ramit Mehr, Nils Y. Lycke
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-09-01 |
Deskripsi
The presence of long-lived memory IgA-producing B cells in the intestine has been difficult to document. Here the authors show that these cells can be induced by oral but not systemic immunization in mice, and characterize unique features that distinguish them from IgA plasma cells.