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Collagen fiber orientation disorder from H&E images is prognostic for early stage breast cancer: clinical trial validation
oleh: Haojia Li, Kaustav Bera, Paula Toro, PingFu Fu, Zelin Zhang, Cheng Lu, Michael Feldman, Shridar Ganesan, Lori J. Goldstein, Nancy E. Davidson, Akisha Glasgow, Aparna Harbhajanka, Hannah Gilmore, Anant Madabhushi
Format: | Article |
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Diterbitkan: | Nature Portfolio 2021-08-01 |
Deskripsi
Abstract Collagen fiber organization has been found to be implicated in breast cancer prognosis. In this study, we evaluated whether computerized features of Collagen Fiber Orientation Disorder in Tumor-associated Stroma (CFOD-TS) on Hematoxylin & Eosin (H&E) slide images were prognostic of Disease Free Survival (DFS) in early stage Estrogen Receptor Positive (ER+) Invasive Breast Cancers (IBC). A Cox regression model named MCFOD-TS, was constructed using cohort St (Nā=ā78) to predict DFS based on CFOD-TS features. The prognostic performance of MCFOD-TS was validated on cohort Sv (Nā=ā219), a prospective clinical trial dataset (ECOG 2197). MCFOD-TS was prognostic of DFS in both St and Sv, independent of clinicopathological variables. Additionally, the molecular pathways regarding cell cycle regulation were identified as being significantly associated with MCFOD-TS derived risk scores. Our results also found that collagen fiber organization was more ordered in patients with short DFS. Our study provided a H&E image-based pipeline to derive a potential prognostic biomarker for early stage ER+ IBC without the need of special collagen staining or advanced microscopy techniques.