Introduction of ORF3a-Q57H SARS-CoV-2 Variant Causing Fourth Epidemic Wave of COVID-19, Hong Kong, China
oleh: Daniel K.W. Chu, Kenrie P.Y. Hui, Haogao Gu, Ronald L.W. Ko, Pavithra Krishnan, Daisy Y.M. Ng, Gigi Y.Z. Liu, Carrie K.C. Wan, Man-Chun Cheung, Ka-Chun Ng, John M. Nicholls, Dominic N.C. Tsang, Malik Peiris, Michael C.W. Chan, Leo L.M. Poon
| Format: | Article |
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| Diterbitkan: | Centers for Disease Control and Prevention 2021-05-01 |
Deskripsi
We describe an introduction of clade GH severe acute respiratory syndrome coronavirus 2 causing a fourth wave of coronavirus disease in Hong Kong. The virus has an ORF3a-Q57H mutation, causing truncation of ORF3b. This virus evades induction of cytokine, chemokine, and interferon-stimulated gene expression in primary human respiratory cells.