Chaperone biomarkers of lifespan and penetrance track the dosages of many other proteins
oleh: Nikolay Burnaevskiy, Bryan Sands, Soo Yun, Patricia M. Tedesco, Thomas E. Johnson, Matt Kaeberlein, Roger Brent, Alexander Mendenhall
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-12-01 |
Deskripsi
In C. elegans the chaperone hsp-16.2 predicts the penetrance of mutations and lifespan after heat shock, but it is not known why cells express different amounts of hsp-16.2. Here the authors show hsp-16.2 tracks differences in global gene expression capacity, rather than differences in signaling or intrinsic noise in adult intestine cells.