Protein context shapes the specificity of SH3 domain-mediated interactions in vivo
oleh: Ugo Dionne, Émilie Bourgault, Alexandre K. Dubé, David Bradley, François J. M. Chartier, Rohan Dandage, Soham Dibyachintan, Philippe C. Després, Gerald D. Gish, N. T. Hang Pham, Myriam Létourneau, Jean-Philippe Lambert, Nicolas Doucet, Nicolas Bisson, Christian R. Landry
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-03-01 |
Deskripsi
The SRC Homology 3 (SH3) domains mediate protein–protein interactions (PPIs). Here, the authors assess the SH3-mediated PPIs in yeast, and show that the identity of the protein itself and the position of the SH3 both affect the interaction specificity and thus the PPI-dependent cellular functions.