Transient genome-wide interactions of the master transcription factor NLP7 initiate a rapid nitrogen-response cascade
oleh: José M. Alvarez, Anna-Lena Schinke, Matthew D. Brooks, Angelo Pasquino, Lauriebeth Leonelli, Kranthi Varala, Alaeddine Safi, Gabriel Krouk, Anne Krapp, Gloria M. Coruzzi
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-03-01 |
Deskripsi
Conventional methods cannot reveal transient transcription factors (TFs) and targets interactions. Here, Alvarez et al. capture both stable and transient TF-target interactions by time-series ChIP-seq and/or DamID-seq in a cell-based TF perturbation system and show NLP7 as a master TF to initiate a rapid nitrogen-response cascade.