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Hypophosphatemic mesenchymal tumors of the skull bone otherwise known as oncogenic osteomalacia and aneurysmal bone cysts of the skull are rare tumors occurring in calvaria. This report consist two rare tumors recently encountered in the Department of Neurosurgery, KIMS Hospital, Secunderabad. Both the patients presented with different clinical pictures. A middle aged person with hypophosphatemic mesenchymal tumor presented with generalized weakness, tremors, pains and fracture left hip joint associated with scalp swelling with hypocalcemia and hypophosphatemia. The other patient with aneurysmal bone cyst was a child and presented with progressive painless enlargement of swelling in the parietal region. Both the tumors were locally aggressive though they were benign histopathologically. Both the patients underwent surgical excision of the tumor. Complete surgical excision reverted the biochemical and clinical picture of the hypophosphatemic mesenchymal tumor patient to normal level. Oncogenic osteomalacia and aneurysmal bone cysts are rare tumors to occur in calvaria, operation is reasonably an easy procedure and complete excision of the tumor will cure the problem.