Ferritin-mediated iron detoxification promotes hypothermia survival in Caenorhabditis elegans and murine neurons
oleh: Tina Pekec, Jarosław Lewandowski, Alicja A. Komur, Daria Sobańska, Yanwu Guo, Karolina Świtońska-Kurkowska, Jędrzej M. Małecki, Abhishek Anil Dubey, Wojciech Pokrzywa, Marcin Frankowski, Maciej Figiel, Rafal Ciosk
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2022-08-01 |
Deskripsi
Strategies to improve cold resistance are of potential biomedical interest. Here the authors demonstrate that ferritin-mediated detoxification of iron, preventing the generation of reactive oxygen species, promotes cold survival in both Caenorhabditis elegans and cultured mammalian neurons.