Lysosomal phospholipase A2 contributes to the biosynthesis of the atypical late endosome lipid bis(monoacylglycero)phosphate
oleh: Jacinda Chen, Amaury Cazenave-Gassiot, Yimeng Xu, Paola Piroli, Robert Hwang, Laura DeFreitas, Robin Barry Chan, Gilbert Di Paolo, Renu Nandakumar, Markus R. Wenk, Catherine Marquer
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-02-01 |
Deskripsi
Lysosomal phospholipase A2 (LPLA2) is the PG to LPG converting enzyme in the BMP biosynthetic pathway, and changes in LPLA2 levels in cells affect cholesterol levels and late endosome/lysosome morphology.