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Acidic amino acid peptides have a high affinity for bone. Previously, we demonstrated that radiogallium complex-conjugated oligo-acidic amino acids possess promising properties as bone-seeking radiopharmaceuticals. Here, to elucidate the effect of stereoisomers of Glu in Glu-containing peptides [(Glu)₁₄] on their accumulation in the kidney, the biodistributions of [⁶⁷Ga]Ga-<i>N</i>,<i>N</i>′-bis-[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-<i>N</i>,<i>N</i>′-diacetic acid-conjugated (<span style="font-variant: small-caps;">l</span>-Glu)₁₄ ([⁶⁷Ga]Ga-HBED-CC-(<span style="font-variant: small-caps;">l</span>-Glu)₁₄), [⁶⁷Ga]Ga-HBED-CC-(<span style="font-variant: small-caps;">d</span>-Glu)₁₄, [⁶⁷Ga]Ga-HBED-CC-(<span style="font-variant: small-caps;">d</span><span style="font-variant: small-caps;">l</span>-Glu)₁₄, and [⁶⁷Ga]Ga-HBED-CC-(<span style="font-variant: small-caps;">d</span>-Glu-<span style="font-variant: small-caps;">l</span>-Glu)₇ were compared. Although the accumulation of these compounds in the bone was comparable, their kidney accumulation and retention were strikingly different, with [⁶⁷Ga]Ga-HBED-CC-(<span style="font-variant: small-caps;">d</span>-Glu-<span style="font-variant: small-caps;">l</span>-Glu)₇ exhibiting the lowest level of kidney accumulation among these compounds. Repeated <span style="font-variant: small-caps;">d</span>- and <span style="font-variant: small-caps;">l</span>-peptides may be a useful method for reducing renal accumulation in some cases.