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A 35 year old man presented with fever, abdominal pain, diarrhea andrecurrent oral ulceration for 2 years. Based on examination and investigations,initial diagnosis of abdominal tuberculosis (TB) was made, butthere was no response to anti-tuberculosis treatment (ATT) which leadsto search for other close differentials. Biopsy of right hemicolectomyspecimen raised strong suspicion of chronic caecal amebiasis. Patientwas started on amoebicidal medication for 3 weeks. He stayed symptomfree on follow up after 3 weeks with healing of the perianal abscess andmarked improvement in oral ulcers.