Network dynamics-based cancer panel stratification for systemic prediction of anticancer drug response
oleh: Minsoo Choi, Jue Shi, Yanting Zhu, Ruizhen Yang, Kwang-Hyun Cho
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-12-01 |
Deskripsi
Genomic alterations underlie the variability of drug responses between cancers, but our mechanistic understanding is limited. Here the authors use the p53 network to study how rewiring of signalling networks by genomic alterations impact their dynamic response to pharmacological perturbation.