Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria
oleh: Pierre-Yves Mantel, Daisy Hjelmqvist, Michael Walch, Solange Kharoubi-Hess, Sandra Nilsson, Deepali Ravel, Marina Ribeiro, Christof Grüring, Siyuan Ma, Prasad Padmanabhan, Alexander Trachtenberg, Johan Ankarklev, Nicolas M. Brancucci, Curtis Huttenhower, Manoj T. Duraisingh, Ionita Ghiran, Winston P. Kuo, Luis Filgueira, Roberta Martinelli, Matthias Marti
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2016-10-01 |
Deskripsi
Inflammatory response to malaria pathogen Plasmodium falciparumcan be triggered by infected red blood cell-derived extracellular vesicles (EVs). This study shows these EVs contain functional microRNA-Argonaute 2 complex that modulates gene expression and alter vascular barrier properties.