The ATM and ATR kinases regulate centrosome clustering and tumor recurrence by targeting KIFC1 phosphorylation
oleh: Guangjian Fan, Lianhui Sun, Ling Meng, Chen Hu, Xing Wang, Zhan Shi, Congli Hu, Yang Han, Qingqing Yang, Liu Cao, Xiaohong Zhang, Yan Zhang, Xianmin Song, Shujie Xia, Baokun He, Shengping Zhang, Chuangui Wang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-01-01 |
Deskripsi
Centrosome clustering is a promising therapeutic target in cancer but how it is regulated remains unclear. Here, the authors show that in response to DNA damage, ATM/ATR stabilize the centrosome clustering regulator KIFC1 leading to increased clustering efficiency and tumour recurrence.