Methylation and PTEN activation in dental pulp mesenchymal stem cells promotes osteogenesis and reduces oncogenesis
oleh: Wen-Ching Shen, Yung-Chih Lai, Ling-Hui Li, Kolin Liao, Hung-Chang Lai, Shou-Yen Kao, John Wang, Cheng-Ming Chuong, Shih-Chieh Hung
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-05-01 |
Deskripsi
Mesenchymal stem cells derived from dental pulp (DP-MSCs) differ in oncogenesic and developmental potential compared to those from bone marrow. Here, the authors show that decreased DNA methylation and histone H3K9Me2 enrichment along with higher PTEN activation in DP-MSCs promotes osteogenesis and reduces oncogenesis.