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The genus <i>Onchocerca</i> includes several species associated with ungulates as hosts, although some have been identified in canids, felids, and humans. <i>Onchocerca</i> species have a wide geographical distribution, and the disease they produce, onchocerciasis, is generally seen in adult individuals because of its large prepatency period. In recent years, <i>Onchocerca</i> species infecting animals have been found as subcutaneous nodules or invading the ocular tissues of humans; the species involved are <i>O. lupi</i>, <i>O. dewittei japonica</i>, <i>O. jakutensis</i>, <i>O. gutturosa</i>, and <i>O. cervicalis</i>. These findings generally involve immature adult female worms, with no evidence of being fertile. However, a few cases with fertile <i>O. lupi</i>, <i>O. dewittei japonica</i>, and <i>O. jakutensis</i> worms have been identified recently in humans. These are relevant because they indicate that the parasite’s life cycle was completed in the new host—humans. In this work, we discuss the establishment of zoonotic <i>Onchocerca</i> infections in humans, and the possibility of these infections to produce symptoms similar to human onchocerciasis, such as dermatitis, ocular damage, and epilepsy. Zoonotic onchocerciasis is thought to be an emerging human parasitic disease, with the need to take measures such as One Health Strategies, in order to identify and control new cases in humans.