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Intraoperative awake anesthesia is a safe and reliable method performed in glioma surgery in brain eloquent areas, for the purpose of a maximum resection of the lesions and protection of brain function. Plasma target⁃controlled infusion (TCI) is used in the course of opening cranium and closing cranium to maintain optimal sedation, which is supplemented by excellent scalp nerve block for analgesia, and a laryngeal mask is used to secure the patient's airway. During cerebral function monitoring and lesion excision, appropriately modifying the plasma concentration of propofol TCI can make the patient achieve optimal sedation. DOI：10.3969/j.issn.1672⁃6731.2012.06.006