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Assessment of Single Cell RNA-Seq Normalization Methods
oleh: Bo Ding, Lina Zheng, Wei Wang
Format: | Article |
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Diterbitkan: | Oxford University Press 2017-07-01 |
Deskripsi
We have assessed the performance of seven normalization methods for single cell RNA-seq using data generated from dilution of RNA samples. Our analyses showed that methods considering spike-in External RNA Control Consortium (ERCC) RNA molecules significantly outperformed those not considering ERCCs. This work provides a guidance of selecting normalization methods to remove technical noise in single cell RNA-seq data.