Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity
oleh: Yuan Zhang, Na Li, Heikyung Suh, Darrell J. Irvine
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-01-01 |
Deskripsi
Immunostimulatory agents used in cancer treatment often elicit serious toxicities, limiting their clinical application. Here, the authors show that the use of liposomes to intravenously deliver surface-anchored IL-2 and anti-CD137 proteins enables anti-cancer immunity and reduces the toxic side effects.