The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice
oleh: Shota Yoshida, Hironori Nakagami, Hiroki Hayashi, Yuka Ikeda, Jiao Sun, Akiko Tenma, Hideki Tomioka, Tomohiro Kawano, Munehisa Shimamura, Ryuichi Morishita, Hiromi Rakugi
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-05-01 |
Deskripsi
Senotherapy, the removal of aged T cells, is an effective approach to attenuate age-related diseases. Here the authors report a CD153 targeting vaccine that prevents the accumulation of senescent adipose tissue T cells in mice on high-fat diet, which is associated with improved glucose tolerance.