Synthesis and characterization of Schiff base analogues of fluoroaniline and their antibiocidal activity against MRSA
oleh: M.V. Santhosh, H.S. NagendraPrasad, S. Nagashree, H.M. Manukumar, L. Mallesh, P. Mallu
| Format: | Article |
|---|---|
| Diterbitkan: | Growing Science 2019-04-01 |
Deskripsi
A group of new fluoroaniline Schiff bases (<b>3a–3f</b>) were synthesized and structurally characterized by various spectroscopic techniques such as <sup>1</sup>H-NMR, LC-MS and FT-IR spectral studies. All compounds were evaluated for <i>in vitro</i> antibacterial activity. Compounds exhibited good to moderate antibacterial activity. Compound <b>3f</b> (Zone of Inhibition = 10.08±0.06 µM) was found to be the most active one, and comparable to the standard Streptomycin (IC50 = 15.95±0.08 µM). The compounds having chloro substituent exhibit good membrane damage property against Methicillin-resistant Staphylococcus aureus (MRSA) confirmed by SEM analysis. Structure-activity relationship (SAR) was rationalized by looking at the varying structural features of the molecules.