Termination of the unfolded protein response is guided by ER stress-induced HAC1 mRNA nuclear retention
oleh: Laura Matabishi-Bibi, Drice Challal, Mara Barucco, Domenico Libri, Anna Babour
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-10-01 |
Deskripsi
Chromatin remodeler Isw1 prevents export of maturing ribonucleoprotein particles. Here, the authors show that Isw1 inhibits the Unfolded Protein Response (UPR) from the nucleus by binding and restricting export of the mRNA encoding the main effector of UPR, thereby tuning adaptation to ER stress.