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INTRODUCTION: TeleMedicine Information System (TMIS) uses information and communicationtechnology (ICT) for providing remote medical consultations. Taking the benefits of ICT, a sick person may distantly get regular telecare medical consultations with his/her remote medico. The backbone of ICT is theInternet, which is open-standard architecture. Due to the openness of the architecture, there are many security vulnerabilities to the TMIS.OBJECTIVES: To provide secured telemedicine consultation between a sick person and a medico and, to maintain the privacy of the sick person information.METHODS: This paper proposes a security enhancement to the TMIS using crypto-biometrics fusion, which consists of Elliptic Curve Cryptography (ECC) algorithm and iris biometrics. The paper also compares the efficiency of ECC with the Rivest-Shamir-Adleman (RSA) algorithm.RESULTS: The result of the simulation proves that the offered model provides a high level and robust securitythan RSA based model.CONCLUSION: This paper provides robust user authentication and achieves the data confidentiality of the TMIS, which uses a cloud computing system for its smooth functioning and wider scope.