Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation
oleh: Lei Huang, Dongning Pan, Qingbo Chen, Lihua J. Zhu, Jianhong Ou, Martin Wabitsch, Yong-Xu Wang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-07-01 |
Deskripsi
The transcriptional co-activator Prdm16 regulates browning of white adipose tissue (WAT). Here, the authors show that Prdm16 interacts with the transcription factor Hlx, which is stabilized in response to β3-adrenergic signaling, to increase thermogenic gene expression and mitochondrial biogenesis in subcutaneous WAT.