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Objective: To investigate the expression of blood routine related indicators in acute and chronic spontaneous urticaria and its clinical significance. Methods: The blood routine test was measured in 178 patients with acute urticaria, 118 patients with chronic urticaria and 119 healthy people. The differences among the third groups were compared. Results: The WBC, NEUT, MONO and NLR were significantly higher in acute urticaria group than those in the chronic urticaria group and the control group (P<0.05). The PLT and PLR in the acute urticaria group was significantly lower than the chronic urticaria group and the control group (P<0.05). The LY and SII were significantly higher in acute urticaria group than those in the control group (P< 0.05), and the BASO were significantly lower in acute urticaria group than those in the control group (P<0.05), but there was no significant difference between the acute urticaria group and the chronic urticaria group (P>0.05).The WBC, NEUT, LY, and MONO were significantly higher in chronic urticaria group than those in the control group (P<0.05). The PLR in the chronic urticaria group was significantly lower than the control group (P<0.05). There was no significant difference between the chronic urticaria group and the control group for the EOS, PLT, BASO, MPV, NLR, SII (P>0.05). The AUC of ROC curve of WBC, NEU, MONO were 0.734, 0.701, 0.709, respectively. Conclusion: The WBC, NEU and MONO of the patients with urticaria could be used for provide more reference for clinical diagnosis and treatment of urticaria.