A fast and efficient colocalization algorithm for identifying shared genetic risk factors across multiple traits
oleh: Christopher N. Foley, James R. Staley, Philip G. Breen, Benjamin B. Sun, Paul D. W. Kirk, Stephen Burgess, Joanna M. M. Howson
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-02-01 |
Deskripsi
Statistical colocalisation is a method to identify causal genes and shared genetic aetiology across traits. Here, the authors describe HyPrColoc, an efficient Bayesian divisive clustering algorithm which integrates summary statistics from genome-wide association studies to detect clusters of colocalised traits from large numbers of traits.