The causes and consequences of Alzheimer’s disease: phenome-wide evidence from Mendelian randomization
oleh: Roxanna Korologou-Linden, Laxmi Bhatta, Ben M. Brumpton, Laura D. Howe, Louise A. C. Millard, Katarina Kolaric, Yoav Ben-Shlomo, Dylan M. Williams, George Davey Smith, Emma L. Anderson, Evie Stergiakouli, Neil M. Davies
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-08-01 |
Deskripsi
Observational studies have found overlap between Alzheimer’s disease and other diseases and phenotypes, although the causal relationships are unclear. Here, the authors perform an age-stratified phenome-wide association study of Alzheimer’s disease (AD) genetic liability and follow-up Mendelian randomization analyses to examine whether these phenotypes have a causal effect on AD.