Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation
oleh: Julia Schewe, Eric Seidel, Sofia Forslund, Lajos Marko, Jörg Peters, Dominik N. Muller, Christoph Fahlke, Gabriel Stölting, Ute Scholl
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-11-01 |
Deskripsi
Mutations in the chloride channel ClC-2 have been associated with familial forms of hyperaldosteronism. Here, Schewe et al. generated a mouse model carrying the most common mutation found in patients and find it recapitulates key features of the disease, providing a unique tool for future studies on its pathogenesis.