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Thyrotoxic crisis is a rare manifestation of thyroid disease. It is an end manifestation of hyperthyroidism. Their life-threatening manifestations and functional reversible features on treatment make every clinician to think about diagnosis of thyrotoxic crisis. Here, we present a rare case of thyrotoxic crisis with neurological and cardiovascular manifestations. His illness was well-controlled with antithyroid drugs. It is thus concluded that thyroid function should be evaluated in otherwise unexplained altered sensorium and tachycardia as a response to treatment is dramatic and most rewarding.