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Evidence - based medicine is the norm of the day. Ever increasing recognition of marked phenotypic heterogeneity amongst patients with defined ‘severe asthma’ calls for precise, individualised patient-based treatment. Although international research has identified several clinical and inflammatory phenotypes of severe asthma, one of the innumerable hurdles that must be overcome in daily practice, is bridging of the knowledge gap between researchers and Physicians dealing with asthmatic patients in their daily clinical practice. While more enterprise is required to comprehend the relation between these phenotypes and their elemental disease mechanisms and pharmacological treatment responses, in-depth cognizance of these clinical and inflammatory phenotypes provide a good embarkation point for addressing disease heterogeneity in severe asthma in day to day practice. This review brings to the reader, comprehensive information on the clinical and inflammatory asthma phenotypes, their associations and related biomarkers and aims to emphasise the importance of recognition of these phenotypes in order to bring individualised patient management to the beside.