Microtubule nucleation and γTuRC centrosome localization in interphase cells require ch-TOG
oleh: Aamir Ali, Chithran Vineethakumari, Cristina Lacasa, Jens Lüders
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-01-01 |
Deskripsi
The molecular mechanisms underpinning the organization of microtubule arrays remain unclear. Here the authors show that in human cells, the microtubule polymerase ch-TOG promotes nucleation of microtubules at the interphase centrosome and the Golgi through a mechanism that involves transient interaction with the microtubule nucleator γTuRC.