Stereoselective synthesis of medium lactams enabled by metal-free hydroalkoxylation/stereospecific [1,3]-rearrangement
oleh: Bo Zhou, Ying-Qi Zhang, Kairui Zhang, Ming-Yang Yang, Yang-Bo Chen, You Li, Qian Peng, Shou-Fei Zhu, Qi-Lin Zhou, Long-Wu Ye
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-07-01 |
Deskripsi
Stereospecific [1,3]-rearrangements are rarely reported method to efficiently build complex organic architectures. Here, the authors describe a metal-free intramolecular hydroalkoxylation/[1,3]-rearrangement sequence affording medium-sized lactams with wide scope, also in an asymmetric fashion.