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The SRTM data set is the highest resolution DEM with global or continental coverage. It is therefore theDEM of choice for continental-scale geomorphological mapping and quantitative analysis. In this study,SRTM data are used for the identification and characterisation of endorheic basins in southern SouthAmerica (south of 19°S). The results show the feasibility of continental-scale quantitative geomorphologybased on SRTM data and provide insights into the distribution of closed basins. The largest endorheicbasin is located in the Puna region and consists of several interconnected sub-basins. This basin accountsfor 38.6 % (7877 km3) of the total volume of the endorheic basins identified in this study. Analyses of thegeographic distribution show a narrow longitudinal distribution between 64.5 and 71.5° W and a multimodallatitudinal distribution which is characterised by two groups of basins at 22.5–27.5°S and 37.5–50.0° Sand an almost complete absence of basins between 27.5 and 37.5° S. Problems and sources ofmisinterpretation arising from data quality and resolution are discussed. Further research, targeting in particularthe genesis and potential for paleoenvironmental reconstruction of closed basins in southern Argentina, iscalled for.