Structural basis for TNA synthesis by an engineered TNA polymerase

oleh: Nicholas Chim, Changhua Shi, Sujay P. Sau, Ali Nikoomanzar, John C. Chaput

Format: Article
Diterbitkan: Nature Portfolio 2017-11-01

Deskripsi

The laboratory-evolved polymerase Kod-RI catalyzes α-L-threose nucleic acid (TNA) synthesis. Here, the authors present Kod-RI crystal structures that give insights into how TNA triphosphates are selected and extended in a template-dependent manner, which will help to engineer improved TNA polymerases for synthetic genetics applications.