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Structural basis for TNA synthesis by an engineered TNA polymerase
oleh: Nicholas Chim, Changhua Shi, Sujay P. Sau, Ali Nikoomanzar, John C. Chaput
Format: | Article |
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Diterbitkan: | Nature Portfolio 2017-11-01 |
Deskripsi
The laboratory-evolved polymerase Kod-RI catalyzes α-L-threose nucleic acid (TNA) synthesis. Here, the authors present Kod-RI crystal structures that give insights into how TNA triphosphates are selected and extended in a template-dependent manner, which will help to engineer improved TNA polymerases for synthetic genetics applications.