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The association between vitamin D receptor (VDR) polymorphism and the risk of cardiovascular diseases (CVD) remains unclear. This study aimed to assess a relationship between the <i>VDR</i> genotypes, plasma concentrations of vitamin D metabolites, and the occurrence of cardiovascular and metabolic disorders. Fifty-eight patients treated for various cardiological afflictions were included. Identification of <i>VDR</i> polymorphisms: <i>ApaI</i>, <i>TaqI</i>, <i>BsmI</i>, and <i>FokI</i> were carried out using the PCR-RFLP method. Plasma concentrations of 25-hydroxyvitamin-D2, 25-hydroxyvitamin-D3, and 3-epi-25-hydroxyvitamin D3 were assessed by the UPLC-MS/MS method. Lower incidence of <i>BsmI</i> AA genotype in the studied patients was observed compared with healthy controls, but the difference was insignificant. Among patients with the TT genotype, frequency of hypertension was higher than among carriers of other <i>ApaI</i> genotypes (<i>p</i> < 0.01). In addition, carriers of the TT <i>ApaI</i>, TC <i>TaqI</i>, and GA <i>BsmI</i> genotypes had an increased risk of obesity, while the presence of the <i>FokI</i> TT genotype was associated with a higher incidence of heart failure and hypertension. In conclusion, the <i>BsmI</i> AA genotype can be protective against CVD, but this observation needs study on a larger group of patients. Particular <i>VDR</i> genotypes were associated with 25-hydroxyvitamin-D levels, and the mechanism of this association should be further investigated.