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In addition to health consequences, the Covid-19 pandemic has had important effects on the environment and lifestyle. Municipal solid waste management faced serious challenges due to consequence of the Covid-19 pandemic. In this study, the effects of the Covid-19 pandemic on the quantity and composition of municipal solid waste in Tehran were investigated. The international experiences of municipal waste management in the Covid-19 pandemic were reviewed and the results were used to develop a guideline for waste management in epidemic conditions adapted to local characteristics. The results showed that changes in the quantity of municipal solid waste affected by the Covid-19 pandemic had temporal and spatial variation. The most change in quantity by 15.81% was seen at the beginning of the pandemic, and non-recyclable waste had the most ratio change among the components of municipal solid waste (144%). The emergence of scattered point sources of infectious waste generation was the most important consequence of the epidemic in municipal solid waste management. These experiences were the basis for defining a guideline for the management of municipal solid waste in biological crises. A guideline in six activities and more than 90 items based on the local characteristics such as available equipment, general culture, local economy, and quantitative changes was defined.