DIAPH1 mediates progression of atherosclerosis and regulates hepatic lipid metabolism in mice
oleh: Laura Senatus, Lander Egaña-Gorroño, Raquel López-Díez, Sonia Bergaya, Juan Francisco Aranda, Jaume Amengual, Lakshmi Arivazhagan, Michaele B. Manigrasso, Gautham Yepuri, Ramesh Nimma, Kaamashri N. Mangar, Rollanda Bernadin, Boyan Zhou, Paul F. Gugger, Huilin Li, Richard A. Friedman, Neil D. Theise, Alexander Shekhtman, Edward A. Fisher, Ravichandran Ramasamy, Ann Marie Schmidt
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2023-03-01 |
Deskripsi
Male and female mice deficient in DIAPH1 are protected from the development of experimental atherosclerosis and display reduced cholesterol levels; these changes are linked to the regulation of SREBP1 subcellular localization.