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Objective: To report a case of Fowler's syndrome after oocyte retrieval. Design: Case report. Setting: Tertiary referral center, King Fahad Medical City. Patient(s): A 23-year-old nulligravida with polycystic ovarian syndrome and primary infertility underwent oocyte retrieval for intracytoplasmic sperm injection (ICSI), and developed Fowler's syndrome (FS). Intervention(s): Intermittent self-catheterization, insertion of sacral neuromodulator (SNM). Main outcome measure(s): Restoration of normal voiding. Result(s): Immediate resolution of patient's symptoms after installation of SNM. Conclusion(s): Fowler's syndrome, although rare, may occur post routine oocyte retrieval; Successful restoration of voiding and resolution of symptoms is possible with SNM installation in similar patients.