Brønsted acid-catalysed enantioselective construction of axially chiral arylquinazolinones

oleh: Yong-Bin Wang, Sheng-Cai Zheng, Yu-Mei Hu, Bin Tan

Format: Article
Diterbitkan: Nature Portfolio 2017-05-01

Deskripsi

Axially chiral arylquinazolinones are structural motifs in several natural products and can also act as chiral ligands. Here, the authors show a chiral phosphoric acid-catalysed strategy to access enantiomerically pure arylquinazolinones by efficient transfer of central chirality into axial chirality.