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To research the influence of high-speed collision between the valve core and valve seat on sealing performance in the closing process of check valve, the collision between the valve core and valve seat during the check valve closing process was calculated based on the Nonlinear Transient Finite Element Method (FEM). It is found that there is a larger optimization space in the structure sealing performance. The objective function was established based on the Multi-Objective genetic algorithm of the Pareto Optimal Concept, and the sensitivity analysis of sealing structure design parameters was carried out by the Optimal Latin Hypercube (OLH) method to select the final optimization design variables which were used to design the optimum size of the check valve core and valve seat. The results show that the sealing performance and structural strength of the check valve were significantly improved after optimization. This research provides a reference for the design and optimization of the control valve sealing structure.