ESR1 fusions drive endocrine therapy resistance and metastasis in breast cancer
oleh: Jonathan T. Lei, Xuxu Gou, Matthew J. Ellis
| Format: | Article |
|---|---|
| Diterbitkan: | Taylor & Francis Group 2018-11-01 |
Deskripsi
Estrogen receptor alpha gene (ESR1) fusion transcripts have been identified in breast cancer but their role in breast cancer is not completely understood. Here, we report a causal role for ESR1 fusions in driving both endocrine therapy resistance and metastasis, and describe a therapeutic strategy to target ESR1 fusion-induced growth.