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Immunomodulatory effects of mesenchymal stem cells in peripheral nerve injury
oleh: Xiangling Li, Yanjun Guan, Chaochao Li, Tieyuan Zhang, Fanqi Meng, Jian Zhang, Junyang Li, Shengfeng Chen, Qi Wang, Yi Wang, Jiang Peng, Jinshu Tang
Format: | Article |
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Diterbitkan: | BMC 2022-01-01 |
Deskripsi
Abstract Various immune cells and cytokines are present in the aftermath of peripheral nerve injuries (PNI), and coordination of the local inflammatory response is of great significance for the recovery of PNI. Mesenchymal stem cells (MSCs) exhibit immunosuppressive and anti-inflammatory abilities which can accelerate tissue regeneration and attenuate inflammation, but the role of MSCs in the regulation of the local inflammatory microenvironment after PNI has not been widely studied. Here, we summarize the known interactions between MSCs, immune cells, and inflammatory cytokines following PNI with a focus on the immunosuppressive role of MSCs. We also discuss the immunomodulatory potential of MSC-derived extracellular vesicles as a new cell-free treatment for PNI.