A non-coding GWAS variant impacts anthracycline-induced cardiotoxic phenotypes in human iPSC-derived cardiomyocytes

oleh: Xi Wu, Fei Shen, Guanglong Jiang, Gloria Xue, Santosh Philips, Laura Gardner, Geneva Cunningham, Casey Bales, Erica Cantor, Bryan Paul Schneider

Format: Article
Diterbitkan: Nature Portfolio 2022-11-01

Deskripsi

Germline variants may pre-dispose patients to an increased risk of developing anthracycline-induced cardiotoxicity. This report provides insights into the mechanism by which a common genetic variant, rs28714259, may confer an increased risk of cardiac damage.