Sensitive period for rescuing parvalbumin interneurons connectivity and social behavior deficits caused by TSC1 loss
oleh: Clara A. Amegandjin, Mayukh Choudhury, Vidya Jadhav, Josianne Nunes Carriço, Ariane Quintal, Martin Berryer, Marina Snapyan, Bidisha Chattopadhyaya, Armen Saghatelyan, Graziella Di Cristo
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-06-01 |
Deskripsi
Regulators of mTORC1, such as Tsc1, are involved in neurodevelopmental disorders associated with autism, intellectual disabilities and epilepsy. The authors identify a role of mTORC1 signaling in the regulation and maintenance of cortical parvalbumin cell connectivity and social behaviour.